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Wednesday, October 11, 2017

Roundup kills your energy system?

What is the Shikimate pathway?

The Shikimate pathway is a seven step metabolic route used by bacteria, fungi, algae, some protozoan parasites and plants for the biosynthesis of folates and aromatic amino acids (phenylalanine, tyrosine, and tryptophan). Since animals need these folates and amino acids, but do not have this pathway, these nutrients must be provided by gut bacteria. Is this how Roundup interferes with a human's energy level, by disturbing gut bacteria?
From Wikipedia: The seven enzymes involved in the shikimate pathway are DAHP synthase, 3-dehydroquinate synthase, 3-dehydroquinate dehydratase, shikimate dehydrogenase, shikimate kinase, EPSP synthase, and chorismate synthase. 
Even since the 1980s, one cause of Myalgic encephalomyelitis (formerly Chronic Fatigue Syndrome) has been thought to be a dysfunction of the human cell mitochondria. But now with more research on how critical gut bacteria is to humans, and how glyphosate (and a diet with sugar) destroys the good gut bacteria, this study might be able to show how Roundup causes its damage, and may be a cause for CFS.

Full study is on Elsevier, which is paywalled. But here is the abstract.

The shikimate pathway is a metabolic route for the biosynthesis of aromatic amino acids (AAAs) (i.e. phenylalanine, tyrosine, and tryptophan). A key enzyme of shikimate pathway (5-enolpyruvylshikimate-3-phosphate synthase, EPSPS) is the target of the widely used herbicide glyphosate. Quinate is a compound synthesized in plants through a side branch of the shikimate pathway. Glyphosate provokes quinate accumulation and exogenous quinate application to plants shows a potential role of quinate in the toxicity of the herbicide glyphosate. Based on this, we hypothesized that the role of quinate accumulation in the toxicity of the glyphosate would be mediated by a deregulation of the shikimate pathway.
In this study the effect of the glyphosate and of the exogenous quinate was evaluated in roots of pea plants by analyzing the time course of a full metabolic map of several metabolites of shikimate and phenylpropanoid pathways. Glyphosate application induced an increase of the 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase (DAHPS, first enzyme of the shikimate pathway) protein and accumulation of metabolites upstream of the enzyme EPSPS. No common effects on the metabolites and regulation of shikimate pathway were detected between quinate and glyphosate treatments, supporting that the importance of quinate in the mode of action of glyphosate is not mediated by a common alteration of the regulation of the shikimate pathway. Contrary to glyphosate, the exogenous quinate supplied was probably incorporated into the main trunk from the branch pathway and accumulated in the final products, such as lignin, concomitant with a decrease in the amount of DAHPS protein.

Study: Pestic Biochem Physiol. 2017 Sep;141:96-102. doi: 10.1016/j.pestbp.2016.12.005. Epub 2016 Dec 10. Abstract:

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