A study by the Center for Science in the Public Interest, says Splenda is not safe. The study was based on mice, who were fed Splenda daily, and later saw a definite increase in certain types of cancers.
Many foods contain Splenda, sometimes listed as sucralose. These items that contain Splenda are often labeled "low calorie" or "diet". This includes many sodas in the US.
Source
US Food Safety.com
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